Executive Order 14355: Unlocking Cures for Pediatric Cancer With Artificial Intelligence

Summary

The order directs the federal government to use artificial intelligence to speed up diagnosis, treatment, cures and prevention for pediatric cancer. It focuses on the Childhood Cancer Data Initiative, increased investment and private-sector engagement, and AI-ready interoperability of health data while patients and parents keep control of their health information. It is implemented consistent with applicable law and subject to the availability of appropriations.

Who it applies to

Applies to federal actors: the MAHA Commission, the Secretary of Health and Human Services, the Assistant to the President for Science and Technology, the Director of the Office of Management and Budget and the Director of the National Institutes of Health. It creates no enforceable rights against the United States or private parties.

Key points

• The MAHA Commission is to develop ways to use AI to improve pediatric cancer diagnoses, treatments, cures and prevention, starting with the Childhood Cancer Data Initiative.
• Priorities include AI-ready data infrastructure, AI analysis of complex biologic systems, and improved clinical trial design and outcomes.
• The MAHA Commission is to identify strategies to increase investment from existing Federal funds and to encourage private-sector use of advanced technologies including AI.
• The Secretary is to work to finalize interoperability standards for patient data used with AI, enabling safe and privacy-compliant exchanges.
• AI is defined by reference to 15 U.S.C. 9401(3).

Key dates

Signed / adopted

Sep 30, 2025

Published (official journal)

Oct 7, 2025