Executive Order 14363: Launching the Genesis Mission

Summary

The order launches the Genesis Mission, a national effort to accelerate AI-driven scientific discovery. It directs the Secretary of Energy to build and operate the American Science and Security Platform, integrating computing resources, AI models, AI agents and federal scientific datasets. It sets deadlines for identifying resources, science and technology challenges and initial operating capability, requires interagency coordination and external partnerships, and mandates annual reporting to the President.

Who it applies to

Applies to federal executive departments and agencies, led by the Department of Energy and coordinated by the Assistant to the President for Science and Technology through the National Science and Technology Council. It also covers partnerships with external entities such as businesses and universities accessing Mission resources.

Key points

• The Secretary of Energy must establish and operate the American Science and Security Platform with high-performance computing, AI agents, foundation models and secure dataset access.
• Within 60 days, the Secretary must identify at least 20 science and technology challenges of national importance and submit them to the APST.
• Within 270 days, the Secretary must seek to demonstrate initial operating capability of the Platform for at least one national challenge.
• The Secretary must set standardized partnership frameworks, intellectual property policies and strict data access and cybersecurity standards for non-Federal collaborators.
• Within 1 year and annually thereafter, the Secretary must report on Platform status, research outcomes and partnerships.

Key dates

Signed / adopted

Nov 24, 2025

Published (official journal)

Nov 28, 2025